Table 3.
Clinical characteristics of patients with Exophiala dermatitidis positive and negative sputum samples.
| Exophiala dermatitidis positive N = 31 | Exophiala dermatitidis negative N = 1281 | ||
|---|---|---|---|
| n (%) | n (%) | P-valueb | |
| Demographic factors | |||
| Age, years (mean, SD) | 28 (13) | 21 (14) | 0.005 |
| Sex, female | 21 (68) | 607 (47) | 0.025 |
| BMI, (mean, SD) | 22 (3) | 20 (4) | 0.003 |
| Genotype, severe CFTR mutationsa | 27 (87) | 1005 (78) | 0.246 |
| Disease characteristics | |||
| CF-related diabetes | 6 (19) | 256 (21) | 1.000 |
| ABPA | 4 (13) | 116 (9) | 0.529 |
| Lung function, FEV1 (mean, SD) | 65 (19) | 71 (25) | 0.167 |
| Microorganisms | |||
| Pseudomonas aeruginosa | 11 (37) | 420 (36) | 0.950 |
| Stenotrophomonas maltophilia | 3 (10) | 98 (8) | 0.733 |
| Staphylococcus aureus | 10 (33) | 404 (34) | 0.926 |
| Burkholderia cepacia | 1 (3) | 22 (2) | 0.442 |
| Non-tuberculous mycobacteria | 1 (3) | 17 (1) | 0.364 |
| Aspergillus spp. | 15 (50) | 314 (27) | 0.005 |
| Medications | |||
| Inhalation corticosteroids | 15 (48) | 330 (31) | 0.044 |
| Azithromycin | 18 (58) | 512 (47) | 0.208 |
| Inhalation antibiotics | 14 (45) | 483 (40) | 0.551 |
a
Severe mutations was defined as 2 CFTR mutations from class I-III.
b
T-test for continuous variables, Chi-2 for binary variables and Fisher's exact for binary variables with less than 10 cases.
BMI: body mass index, CFTR: Cystic fibrosis transmembrane conductance regulator, CF: Cystic fibrosis, ABPA: allergic bronchopulmonary aspergillosis, FEV1: forced expiratory volume in 1 second.