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Histidine can be decarboxylated to histamine which may be subsequently methylated to N1-methylhistidine. (A) Conversion of histidine to histamine by histidine decarboxylase. Pyridoxal phosphate is the cofactor. (B) Inactivation of histamine by histamine N-methyltransferase in brain. The methyl donor is SAM, which is converted to SAH. SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine.
