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. 2020 Sep 28;52(10):1018–1023. doi: 10.1038/s41588-020-0699-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — The central blue bars represent the two haplotypes of chromosome 10 with the gray lines indicating the paired allelic genes. The distribution of deleterious or dysfunctional mutations (brown), annotated genes (yellow), preferentially expressed alleles (green), methylation level of three contexts and differentially methylated regions are arranged symmetrically for each haplotype. The methylation level and the number of DMRs of methylated sites in CG (light blue), CHG (red) and CHH (orange) contexts are indicated by cumulative column chart. Number of DMRs on one haplotype only involves the DMRs with hyper-methylation. All of the numbers were determined in 200 kb windows.