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. 2020 Sep 30;10:16136. doi: 10.1038/s41598-020-73014-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Genes contributing to the higher variance in responses following LPS and SEB stimulation for healthy volunteers (HV) and septic shock patients. PCA of 10 HV (circles) and 30 septic shock patients (triangles) response (stimulation/NUL) to (A) LPS stimulation (red) and (B) SEB stimulation (green). Every donor is labelled. The percentage of variance captured by each PC axis is indicated, as well as the total variance. Vector position for each donor were plotted and visualisation was executed with Partek. The most important variables are plotted (representing 15% of the total variables weight for PC1 and PC2) for (C) LPS response and (D) SEB response. LPS lipopolysaccharide, SEB staphylococcal enterotoxin B, PCA principal component analysis, PC principal component.