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. 2020 Sep 30;10:16162. doi: 10.1038/s41598-020-73116-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Hypermethylated and hypomethylated regions specific to the G34 subgroup. (a) G34-hyper-DMRs and G34-hypo-DMRs. Raw methylation levels are used for hierarchical clustering of DMRs. Rows and columns of the heatmap indicate DMRs and samples, respectively. Ladders on the right side of each panel indicate CGIs and LADs. G34R, N = 4; K27M, N = 13; WT, N = 8; Normal, N = 8. (b) GO enrichment analysis of DMRs. See Table S3 for details. (c) Transcription factor-binding motifs enriched in DMRs.