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. 2020 Sep 30;3:541. doi: 10.1038/s42003-020-01243-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a–c OPT images of splenic lobes of control (a), SHD-STZ (b) and MLD-STZ (c) pancreata 3 weeks post-STZ administration. Dashed boxes in (a–c) indicate the locations imaged by light sheet fluorescence microscopy (LSFM), displaying representative centrally-located large (a′–c′) and peripherally located small islets (a″–c″). LSFM images are shown as maximum intensity projections, from representative OPT samples (n = 3 pancreata per group). Note, samples were LSFM-scanned at different exposure times and are not intended for signal intensity comparisons.