. 2020 Oct 1. Online ahead of print. doi: 10.1016/j.cgh.2020.09.048

Table 2.

Comparisons and Outcomes From FIT Studies Included in the Systematic Review

Author, Year	Comparator Time From FIT	Alternate Time Cutoffs	Outcomes	Detailed Results	Summary
Corley, 2017¹³	Within 1 mo (excluding within 1–7 d)	Within 2, 3, 4–6, 7–9, 10–12, >12 mo	CRC incidence (within 6 mo of colonoscopy) CRC stage Advanced adenoma(s)	• 30 of 1000 persons if colonoscopy performed within 1 mo (excluding within 1–7 d) • No significant differences in colonoscopy within 2, 3, or 6 mo (cases per 1000 were 28, 31, and 31, respectively) • Significantly higher CRC at 10–12 mo or >12 mo (cases per 1000 were 49 and 76, respectively): AORs were 1.48 (95% CI, 1.05–2.08) and 2.25 (95% CI, 1.89–2.68) • Advanced stage in 8 of 1000 persons if colonoscopy performed within 1 mo • No significant differences in colonoscopy within 2, 3, or 6 mo (cases per 1000 were 7, 7, and 9, respectively) • Significantly higher advanced CRC at 10–12 mo or >12 mo (cases per 1000 were 15 and 31, respectively): AORs were 1.55 (95% CI, 1.05–2.28) and 3.22 (95% CI, 2.44–4.25) • 81 of 1000 persons if colonoscopy performed within 1 mo • No/borderline significant differences in colonoscopy within 2, 3, 6, or 12 mo (cases per 1000 were 91, 93, 84, and 95, respectively) • Significantly higher rate of advanced adenomas at >12 mo (cases per 1000 were 116): AORs were 1.32 (95% CI, 1.15–1.52)	Delays to colonoscopy of over 9 mo after positive FIT was significantly associated with higher CRC incidence and more advanced stage at diagnosis (compared with performing colonoscopy within 1 mo).
Kaalby, 2019¹⁶	Within 1 mo	Within 2, 3, >3 mo	CRC incidence (at colonoscopy) CRC stage Advanced adenoma(s)	• 41 of 1000 persons if colonoscopy performed within 1 mo • Significantly higher CRC within 2, 3 or >3 mo (cases per 1000 were 101, 111, and 201, respectively): AORs were 2.49 (95% CI, 2.56–2.75), 2.68 (95% CI, 2.31–3.10), and 5.32 (95% CI, 4.89–5.79) • Mean time to colonoscopy in the >3 mo group was 174 (interquartile range, 91–1348) d • Advanced stage in 14 of 1000 persons if colonoscopy performed within 1 mo • Significantly higher rates of advanced stage CRC within 2, 3 or >3 mo (cases per 1000 were 28, 29, and 39, respectively): AORs were 1.93 (95% CI, 1.62–2.30), 1.92 (95% CI, 1.46–2.53), and 2.59 (95% CI, 2.19–3.06) • 286 of 1000 persons if colonoscopy performed within 1 mo • Significantly more advanced adenomas within 3 or >3 mo (cases per 1000 were 303 and 378, respectively): AORs were 1.16 (95% CI, 1.09–1.23) and 1.59 (95% CI, 1.50–1.68)	Delays to colonoscopy of 2 mo or more after positive FIT was significantly associated with higher incidence of CRC, more advanced stage at CRC diagnosis, and more advanced adenomas (compared with performing colonoscopy within 1 mo).
Kim, 2019¹⁷	Within 1 mo	Within 2, 3–5, 6, >6 mo	CRC incidence (at colonoscopy) CRC stage Advanced adenoma(s)	• 45 of 1000 persons if colonoscopy performed within 1 mo • No significant changes in CRC within 2, 3–5, 6, or >6 mo (cases per 1000 were 49, 42, 89, and 76, respectively): AORs were 0.91 (0.52–1.58), 0.63 (95% CI, 0.33–1.21), 2.10 (95% CI, 0.69–6.39), and 1.93 (95% CI, 0.74–4.93), P = .29 • Advanced stage in 15 of 1000 persons if colonoscopy performed within 1 mo • No significant changes in advanced stage CRC within 2, 3–5, 6, or >6 mo (cases per 1000 were 13, 15, 0, and 22, respectively), P = .90 • 127 of 1000 persons if colonoscopy performed within 1 mo • Borderline but nonsignificant increase in advanced adenomas within 2, 3–5, 6, or >6 mo (cases per 1000 were 137, 149, 125, and 196, respectively) • AOR of CRC or advanced adenomas at >6 mo: 1.73 (95% CI, 0.91–3.27)	Delays to colonoscopy of 6 mo or more after positive FIT was associated with a nonsignificant trend towards higher incidence of CRC and advanced adenomas combined (compared with performing colonoscopy within 1 mo). This study was limited by sample size.
Lee, 2019¹⁴	Within 3 mo (excluding within 30 d)	4–6, 7–9, 10–12, >12 mo	CRC incidence (at colonoscopy) CRC stage Advanced adenoma(s)	• 50 of 1000 persons if colonoscopy performed within 3 mo (excluding within 30 d) • No significant changes in CRC within 4–6, 7–9, or 10–12 mo (cases per 1000 were 49, 68, and 74, respectively) • Significantly higher CRC incidence at >12 mo, with 98 cases per 1000: AOR was 2.17 (95% CI, 1.44–3.26) • Advanced stage in 11 of 1000 persons if colonoscopy performed within 3 mo • Significantly higher rates of advanced stage CRC within 7–9, 10–12, or >12 mo (cases per 1000 were 24, 27, and 31, respectively): AORs were 2.09 (95% CI, 1.43–3.06), 1.97 (95% CI, 1.06–3.65), and 2.84 (95% CI, 1.43– 5.64) • 140 of 1000 persons if colonoscopy performed within 3 mo • No significant increases in advanced adenomas within 4–6, 7–9, 10–12, or >12 mo (cases per 1000 were 135, 149, 155, and 149, respectively)	Delays to colonoscopy of 12 mo or more after positive FIT was significantly associated with higher CRC incidence (compared with performing colonoscopy within 3 mo). However, more advanced CRC stage at diagnosis was observed after 6 mo.
Zorzi, 2020¹⁵	Within 1 mo	Within 2, 3, 4, 5, 6, 7–9, >9 mo	CRC incidence (at colonoscopy) CRC stage Advanced adenoma(s)	• 41 of 1000 persons if colonoscopy performed within 1 mo • No significant differences in colonoscopy within 2, 3, 4, 5, 6, or 7–9 mo (cases per 1000 were 38, 36, 39, 38, 26, and 43, respectively) • Significantly higher CRC at >9 mo (cases per 1000 were 78): AORs were 1.75 (95% CI, 1.15–2.67) • Advanced stage in 4 of 1000 persons if colonoscopy performed within 1 mo • No significant differences in colonoscopy within 2, 3, 4, 5, 6, or 7–9 mo (cases per 1000 were 4, 4, 3, 1, and 5, respectively) • Significantly higher advanced CRC at 7–9 mo or >9 mo (cases per 1000 were 11 and 13, respectively): AORs were 2.35 (95% CI, 1.15–4.80) and 2.79 (95% CI, 1.03–7.57) • 258 of 1000 persons if colonoscopy performed within 1 mo • No significant differences in colonoscopy within 2, 3, 4, 5, 6, 7–9, or >9 mo	Delays to colonoscopy of over 9 mo after positive FIT were significantly associated with higher incidence of CRC and advanced stage of CRC at diagnosis (compared with performing colonoscopy within 1 mo).

AOR, adjusted odds ratio; CI, confidence interval; CRC, colorectal cancer; FIT, fecal immunochemical test.