Supplementary Table 3.

Comparisons and Outcomes From FOBT Studies Included in the Systematic Review

Author, Year	Comparator Time From FIT	Alternate Time Cutoffs	Outcomes	Detailed Results	Summary
Gellad, 200942	Continuous	Continuous	Incidence of CRC or advanced adenoma(s) (at colonoscopy)	•Mean time to colonoscopy 236 ± 112 d •Advanced adenomas found in 11% of patients •CRC found in 4% of patients •Longer time to colonoscopy associated with more advanced findings (analysis of variance P = .04) •Nonsignificant trend toward longer time to colonoscopy and presence of advanced neoplasia: OR was 1.07 (95% CI, 0.98–1.18) for each additional 1-mo wait	Incremental delays to colonoscopy of 1 mo after positive FOBT were associated with a nonsignificant trend toward higher incidence of CRC and advanced adenomas combined. This study was limited by sample size.
Flugelman, 201918	Within 3 mo	Within 4–6, 7–12, >12 mo	CRC-specific mortality	•For the 4–6 and 7–12-mo groups, HRs for CRC-specific mortality were 0.81 (95% CI, 0.55–1.19) and 0.83 (95% CI, 0.50–1.41) •HR for >12 mo group was 1.53 (95% CI, 1.13–2.12)	Delays to colonoscopy of 12 mo or more after positive FOBT were significantly associated with higher CRC-specific mortality (compared with performing colonoscopy within 3 mo).
Beshara, 202017	Within 3 mo	4–6, 7–9, 10–12, 13–18, 19–24 mo	CRC incidence (at colonoscopy) CRC stage	•39 of 1000 persons if colonoscopy performed within 3 mo •No significant changes in CRC within 4–6, 7–9, or 10–12 mo (cases per 1000 were 25, 35, and 42, respectively): AORs were 0.66 (95% CI, 0.51–0.85), 1.01 (95% CI, 0.70–1.46), and 1.20 (95% CI, 0.77–1.88) •Significantly higher CRC incidence within 13–18 or 19–24 mo (cases per 1000 were 73 and 74, respectively): AORs were 1.93 (95% CI, 1.39–2.69) and 1.78 (95% CI, 1.13–2.80) •Advanced stage in 9 of 1000 persons if colonoscopy performed within 3 mo •Significantly higher CRC incidence within 13–18 mo (18 cases per 1000): AOR was 2.11 (95% CI, 1.12–3.99)	Delays to colonoscopy of 12 mo or more after positive FOBT were significantly associated with higher CRC incidence and more advanced stage of diagnosis (compared with performing colonoscopy within 3 mo).

AOR, adjusted odds ratio; CI, confidence interval; CRC, colorectal cancer; FIT, fecal immunochemical test; FOBT, fecal occult blood test; HR, hazard ratio; OR, odds ratio.