Fig. 3.

Time- and concentration-dependent upregulation of p75NTR and sortilin by VPA. a, b: SH-SY5Y and LAN-1 cells were incubated in the presence of 1 mM VPA for the indicated periods of time. Zero time samples were incubated with vehicle and used as control. c-f: SH-SY5Y (c, e) and LAN-1 (d, f) were incubated for 24 h in the presence of either vehicle or VPA at the indicated concentrations. Cell lysates were analysed for p75NTR and sortilin expression by Western blot. Values are the mean ± SD of four independent experiments. *p < 0.05 vs. control