Table 2.
Effect of acetazolamide on the distribution of [11C]4 in male ddY mice 2 min after injection
| Tissue | Vehicle | Acetazolamide | Increase (%) | P |
|---|---|---|---|---|
| Blood | 0.35 ± 0.06 | 0.33 ± 0.03 | 94.3 | N.S. |
| Heart | 1.62 ± 0.37 | 1.51 ± 0.20 | 93.2 | N.S. |
| Lung | 8.99 ± 1.96 | 4.58 ± 1.44 | 51.0 | < 0.05 |
| Liver | 0.78 ± 0.10 | 1.05 ± 0.16 | 134.6 | N.S. |
| Kidney | 6.46 ± 0.99 | 5.85 ± 1.21 | 90.6 | N.S. |
| Brain | 1.90 ± 0.36 | 2.60 ± 0.13 | 136.8 | < 0.05 |
| Brain/blood | 5.53 ± 1.12 | 8.01 ± 0.79 | 144.9 | < 0.05 |
The radioactivity levels are expressed as SUVs
Data represent the mean ± SD (n = 5)
Unpaired t test corrected for multiple comparison using the Holm–Sidak method
N.S. not significant