Table 3.
Metabolite analysis of [11C]4 in male ddY mice
| Components | Rf value | Plasma metabolites (%) | Brain metabolites (%) | ||
|---|---|---|---|---|---|
| 5 min | 15 min | 5 min | 15 min | ||
| HM1 | 0.09 | 7.87 ± 2.17 | 26.65 ± 3.40 | 0.03 ± 0.02 | 0.03 ± 0.02 |
| HM2 | 0.25 | 53.25 ± 6.59 | 59.06 ± 6.13 | 0.01a | 0.13 ± 0.02 |
| HM3 | 0.36 | 0.54 ± 0.26 | 0.04a | 0.09a | 0.02a |
| Unchanged | 0.44 | 38.29 ± 6.52 | 14.76 ± 2.23 | 99.87 ± 0.03 | 99.84 ± 0.04 |
| LM | 0.63 | 0.05 ± 0.03 | 0.01 ± 0.01 | N.D. | N.D. |
Data represent the mean ± SD (n = 3)
N.D. not detected, HM hydrophilic metabolite, LM lipophilic metabolite
aDetected in two samples