Table 3.

Metabolite analysis of [¹¹C]4 in male ddY mice

Components	Rf value	Plasma metabolites (%)		Brain metabolites (%)
		5 min	15 min	5 min	15 min
HM1	0.09	7.87 ± 2.17	26.65 ± 3.40	0.03 ± 0.02	0.03 ± 0.02
HM2	0.25	53.25 ± 6.59	59.06 ± 6.13	0.01a	0.13 ± 0.02
HM3	0.36	0.54 ± 0.26	0.04a	0.09a	0.02a
Unchanged	0.44	38.29 ± 6.52	14.76 ± 2.23	99.87 ± 0.03	99.84 ± 0.04
LM	0.63	0.05 ± 0.03	0.01 ± 0.01	N.D.	N.D.

Data represent the mean ± SD (n = 3)

N.D. not detected, HM hydrophilic metabolite, LM lipophilic metabolite

^aDetected in two samples