TABLE 2.
Phenotypic and genotypic characteristics of mutants resistant to BDQ obtained from M. tuberculosis clinical isolates IC1 and IC2.
| M. tuberculosis strains | MIC (μg/ml) | Mutation | Amino acid substitution |
| H37Rv | 0.06 | ||
| IC1 | 0.06 | ||
| IC2 | 0.06 | ||
| IC1 B | 8 | atpE: g187c | A63P |
| IC1 C | 4 | atpE: g187c | A63P |
| IC1 D | 4 | atpE: g187c | A63P |
| IC1 F | 4 | atpE: g187c | A63P |
| IC1 G | 4 | atpE: g187c | A63P |
| IC1 H | 2 | atpE: a83c | D28A |
| IC2 Q | 0.5 | atpE: a83g | D28G |
| IC1 L | 0.5 | rv0678: c400t | R124Stop |
| IC1 M | 0.5 | rv0678: g120c | L40F |
| IC1 N | 0.5 | rv0678: a271c | T91P |
| IC1 O | 0.5 | rv0678: g61t | E21Stop |
| IC2 P | 0.25 | rv0678: g197a | G66E |