Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;11:570018. doi: 10.3389/fimmu.2020.570018

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Khatri, Staal and van Dongen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Currently known antibodies targeted against _CoV2S protein do not hinder the complete interaction site between _CoV2S and _hACE2 proteins. (A) Visualizing interacting surface between _CoV2S and _hACE2 proteins (PDB ID: 6LZG). Two highly dominant interacting regions (DIR) in _CoV2S protein are referred as DIR-1 and DIR-2. Two antibodies in the top panel bind to Spike protein epitopes that do not interact with _hACE2. Multiple X-ray crystallographic structures for one antibody were aligned in PyMOL (59). Five antibodies in the bottom panel from four different studies interact with the interaction region between _CoV2S and _hACE2 proteins. These five antibodies interact with the DIR-2 region, but not with residues in the DIR-1 region. The surface area of the interacting region in _CoV2S protein is 1,773Å² surface area, whereas an antibody can cover 600–900 Å² surface. (B) Schematic diagram to explain how the currently known antibodies can completely hinder _CoV2S-_hACE2 interaction with the help of a partner antibody.