Table 1.

Summary of clinical experiments.

Participant number	Exp. number	Contrast agent(s)	Dose	Oral/IV	Other products consumed	Sensor position	Relevant figures	Additional Information
1	i	Fluorescein ICG	500 mg 25 mg	IV	N/A	Finger Arm Wrist	2	–
2	i	Fluorescein	500 mg	IV	N/A	Finger Arm Wrist	–	–
3	i	Fluorescein	500 mg	IV	N/A	Finger Arm Wrist	–	–
4	i	Fluorescein	2.5 g	Oral	100 ml water	Finger	3A-C	–
	ii	Fluorescein	330 mg	Oral	65 ml water	Finger	S3	Oral absorption experiment (no dye ingested)
	iii	Fluorescein	5 mg, then 25 mg	Oral	50 ml water (5 mg in 25 ml, then 25 mg in 25 ml)	Arm	3D	Limit of detection experiment
	iv	Fluorescein ICG	500 mg 250 mg	Oral	130 ml water, 60 g sugar	Arm	S4 S5	–
	v	Fluorescein	500 mg	Oral	100 ml water	Finger Arm Wrist	4	Confocal endo-microscopy experiment
	vi	Fluorescein	500 mg	Oral	1.5 g paracetamol, milkshake (see Table S1)	Finger	5A	Blood samples collected
5	i	Fluorescein	500 mg	Oral	100 ml water	Arm	–	–
	ii	Fluorescein ICG	500 mg 350 mg	Oral	140 ml water, 100 g sugar	Arm	S4 S5	–
	iii	FITC-Dextran	1 g	Oral	100 ml water, 60 g sugar	Finger	6 S5	Urine samples collected
6	i	Fluorescein	500 mg	Oral	100 ml water	Finger	5B	–
	ii	Fluorescein	500 mg	Oral	100 ml water, 60 g sugar	Finger	5B	–

Exp experiment, IV intravenous.