Table 3.

Heritable disorders associated with intracranial aneurysms.

Disorder	Inheritance	Special features
α-Glucosidase deficiency	AR	Aneurysms often fusiform
α1-Antitrypsin deficiency	AR	Heterozygotes may be affected
Alkaptonuria	AR
Anderson-Fabry disease	XLR	Aneurysms often fusiform; Carriers may be affected
Autosomal polycystic kidney disease	AD
Ehlers-Danlos syndrome type IV	AD
Familial idiopathic non-arteriosclerotic cerebral calcification syndrome	?
Hereditary hemorrhagic telangiectasia	AD
Marfan's syndrome	AD
Neurofibromatosis type 1	AD
Noonan's syndrome	AD
Pseudoxanthoma elasticum	AD, AR
Tuberous sclerosis	AD	Aneurysms often fusiform
Wermer's syndrome (multiple endocrine neoplasia type 1)	AD
3M syndrome	?

AD, autosomal dominant; AR, autosomal recessive; XLR, X-linked recessive.