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. 2020 Sep 17;14:579867. doi: 10.3389/fnins.2020.579867

FIGURE 3.

FIGURE 3

Changes in high-frequency oscillatory activity in the SO cycle in the mPFC of A30P mice. (A,B) Example LFP (red = Up-state and blue = Down-state) and corresponding spectrograms showing the power of oscillatory activity in the 0.1–130 Hz frequency spectrum, in the PrL region in (A) WT and (B) an A30P mouse. (C) The mean area power under the curve in the beta frequency range (15–29.9 Hz) in WT and (D) A30P mice. (E) The mean area power under the curve in the gamma frequency range (30–79.9 Hz) in WT and (F) A30P mice in the normalized SO cycle (0 = start of Down-state, 50 = Down to Up-state transition, 100 = end of Up-state). (G) The average latency to peak power in the normalized SO cycle in the beta and (H) gamma frequency ranges in WT (blue) and A30P (gray) mice. Each variable is calculated as an average for each of the mPFC sub-regions (ACC, PrL, IL, DP) for A30P (N = 13) and WT (N = 8) animals. Error bars indicate the SEM and asterisks indicate significance: ∗p < 0.05, ∗∗p < 0.01.