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. 2020 Sep 30;11:4909. doi: 10.1038/s41467-020-18626-y

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, In vivo pharmacokinetic curves of liposomes, R-NVs, P-NVs, M1-NVs, and SαV-C-NVs. b, c In vivo fluorescence imaging (b) and corresponding fluorescence intensities (c) of the mice 2 h after i.v. injection of equivalent dose of fluorescence-labeled liposomes and multiple NVs. d, e In vivo fluorescence imaging of the mice (d) and corresponding fluorescence intensities (e) 2 h after i.v. injection of equivalent dose of fluorescently labeled R-NVs and P-NVs. f, Schematic showing the CTC analysis schedule in a recurrence mouse model after incomplete surgery. g Immunofluorescence images of single WBC and CTC captured from blood samples. Scale bar, 10 µm. h Flow cytometric analysis of M2-like macrophages (CD206⁺) and M1-like macrophages (CD80⁺) in tumor gating on F4/80⁺CD11b⁺CD45⁺ cells. i Secretion levels of IL-10 and IL-12 in different treatment groups. j Immunohistochemistry images of tumors showing CD8⁺ T cells in different treatment groups. Scale bar, 50 µm. k Flow cytometric analysis of CD8⁺ and CD4⁺ T cells in tumor gating on CD45⁺ cells. l, Flow cytometric analysis of CD80⁺CD86⁺ dendritic cells in tumor gating on CD45⁺CD11c⁺ cells. All data are presented as mean ± S.D. (n = 4). Statistical significance was calculated via ordinary one-way ANOVA with a Dunnett’s test c, l or unpaired two-tailed t test e, h, i, k. ns, no significance; *P < 0.05; **P < 0.01; ***P < 0.001.