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. 2020 Sep 30;11:4909. doi: 10.1038/s41467-020-18626-y

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© This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply 2020

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Fig. 6 — a Schematic showing the treatment schedule in a recurrence and metastasis mouse model after incomplete surgery. b In vivo bioluminescence imaging of 4T1 recurrence and metastasis in different treatment groups. c, d Individual c and average d tumor growth kinetics in different groups. Growth curves were stopped when the first mouse died in the corresponding group. e Metastasis rates after indicated treatments. f Ink-stained lung photographs collected from the mice after different treatments. Red arrowheads indicate tumor foci in the lung. g, Numbers of lung metastatic foci after different treatments. h Survival curves for different treatment groups. i Relative mRNA expression of Ifnb1, Cxcl9, and Cxcl10 in tumor 4 h after indicated treatments. Data are presented as mean ± S.D. (d, h, n = 7 for the groups treated with hNVs + cGAMP and hNVs@cGAMP, n = 5 for the other groups; g, n = 5 for the PBS group, n = 3 for the hNVs@cGAMP group, and n = 4 for the other groups; i, n = 6). Statistical significance was calculated via 2 way ANOVA with a Tukey’s test d or ordinary one-way ANOVA with a Tukey’s test g, i or log-rank (Mantel–Cox) test h. **P < 0.01; ***P < 0.001.