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. 2020 Sep 30;10:16112. doi: 10.1038/s41598-020-72629-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of PM014 on IR-induced apoptosis. (A) Representative TUNEL staining (green) of irradiated mouse lung tissues. Magnification, × 400 (Scale bar 50 μm). The treatment groups were Control (untreated); IR, (75 Gy irradiation); IR + PM014 (IR + 200 mg/kg PM014); PM014 (200 mg/kg PM014 only). Immunohistochemistry (B) and western blotting (C) using irradiated mouse lung tissues. Magnification, × 400 (Scale bar 100 μm). Full length blots are presented in Supplementary Fig. S9. The treatment groups were Control (untreated); IR, (75 Gy irradiation); IR + PM014 (IR + 200 mg/kg PM014); PM014 (200 mg/kg PM014 only). (D) The pro-apoptotic protein Noxa (green) was co-stained with pro-SP-C (red), a marker for type II AECs, using irradiated mouse lung tissue. Magnification × 400 (Scale bar, 50 μm).