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. 2020 Sep 30;10:16142. doi: 10.1038/s41598-020-72852-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Performance comparison of the metabolic biomarker panel and PlGF for discriminating preeclampsia from healthy controls in the mid-trimester cohort (A) Receiver operating characteristic (ROC) curve analysis. The biomarker panel of 5 discriminatory circulating metabolites were tested against PlGF levels in their ability to predict the development of PE. (B) Validation based on permutation test with 100 time-random sampling (C) Summarized features of ROC curve analysis of two models.