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. 2020 Sep 30;10:16142. doi: 10.1038/s41598-020-72852-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Performance comparison of the metabolic biomarker panels and sFlt-1/PlGF ratio for discriminating preeclampsia from non-preeclampsia in the at-delivery cohort. (A) Receiver operating characteristic (ROC) curve analysis. The same metabolic biomarker derived from the mid-trimester cohort study is re-formulated for at-delivery cohort using binary logistic regression analysis (biomarker panel¹). New biomarker panel was generated based metabolite set determined from at-delivery cohort study (biomarker panel²). (B) Validation based on permutation test with 100 time-random sampling (C) Summarized features of ROC curve analysis of the tested models.