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Rejection mechanisms involved in VCA.
| Rejection classification | Primary findings |
|---|---|
| Type of rejection | |
| Acute Rejection | Endothelial injury, dermal perivascular CD4/CD8 infiltrates |
| Chronic Rejection | Microthromboses, graft vasculopathy |
| Immunologic mechanism | |
| Cell-Mediated | CD4/CD8, adhesion molecules, pro-inflammatory cytokines |
| Antibody-Mediated | B cells, C4d deposits, DSA |
DSA, Donor specific antibodies.
