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. 2020 Sep 30;11(9):818. doi: 10.1038/s41419-020-03017-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a RPMI-8226 cells were subcutaneously inoculated into the right flank of female nude mice to establish a multiple myeloma xenografted model. When tumors were palpable, mice (n = 5 for each group) were orally administered vehicle or Nam (2 mg/kg or 4 mg/kg body weight) in CMC-Na for a continuous 20 d. During the experiments, tumor sizes were monitored every other day. b The body weight curve over the experiment. c The blood species from mice were subjected to measurement of the contents of AST, ALT, ALP, urea, total bilirubin (TB) and total proteins (TP). d Tumor tissues from xenografted mice were subjected to the measurement of c-Maf and Otub1 proteins by IB assays. **p < 0.001 and NS, not significant, compared with the control.