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. 2020 Sep 17;11:574176. doi: 10.3389/fphar.2020.574176

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Copyright © 2020 Duan, Zhu, Yang, Liu, Bai, Qu, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mRNA expression of CYP1A2, CYP2C9, CYP2E1, CYP3A4, and UGT1A1 following treatment with Rif and CITCO. HepG2 cells treatment with Rif or COTCO in normoxia, and the mRNA expression of CYP1A2, CYP2C9, CYP2E1, CYP3A4, and UGT1A1 were detected. The mRNA expression levels of CYP450 and UGT1A1 genes are shown using the indicated pseudocolor scale from 0 (green) to 2 (red) relative to the value for HepG2 cells in the control group. The color scale represents the relative mRNA expression levels, with green indicating down-regulated genes, red indicating up-regulated genes, dark yellow indicating over 2-fold up-regulated genes, and black indicating unchanged genes. Rif (rifampicin): PXR agonist, CITCO (6-(4-chlorophenyl)-imidazo (2,1-b) thiazole-5-carbaldehyde): CAR agonist.