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. 2020 Sep 17;11:574176. doi: 10.3389/fphar.2020.574176

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Copyright © 2020 Duan, Zhu, Yang, Liu, Bai, Qu, Wang and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The promoter activity of CYP1A2, CYP2C9, CYP2E1, CYP3A4, and UGT1A1 following agonist treatment under different oxygen concentrations. HepG2 cells were treated with RIF or CITCO under 2, 5, and 21% O₂, after which the drug-containing medium was removed, and the D-luciferase activity of CYP450 and UGT1A1 were measured. n = 3 independent experiments in triplicate; a representative graph is shown. Rif (rifampicin): PXR agonist, CITCO (6- (4-chlorophenyl)-imidazo (2,1-b) thiazole-5-carbaldehyde): CAR agonist.