Figure 3.

mRNA expression of CYP1A2, CYP2B1, CYP2C11, CYP2C22, CYP2D1, CYP2E1, CYP3A1, UGT1A1, PXR, and CAR in rats. P: plain group (altitude: 390 m, PaO₂: 20 kPa), MAH: acute moderate-altitude hypoxia group (altitude: 2,800 m, PaO₂: 15.1 kPa; Rats were exposed to moderate altitude for 24 h), MCH: chronic moderate-altitude hypoxia group (altitude: 2,800 m, PaO₂: 15.1 kPa; Rats were exposed to moderate altitude for 30 days), HAH: acute high-altitude hypoxia group (altitude: 4,300 m, PaO₂: 12.4 kPa; Rats were exposed to high altitude for 24 h), HCH: chronic high-altitude hypoxia group (altitude: 4300 m, PaO₂: 12.4 kPa; Rats were exposed to high altitude for 30 days). The data were analyzed using a one-way analysis of variance (ANOVA), and the differences between the means of two groups were compared using LSD tests. ^* indicates the significance of experimental groups, compared with that of the control. Values are expressed as Mean ± SEM (n = 10). Levels are considered significant at ^* p < 0.05.