Figure 6.
Expression of CYP1A2, CYP2B6, CYP2C9, CYP3A4, UGT1A1, PXR, and CAR in HepG2 cells following treatment with KCZ and RA. (A) The protein expression levels of CYP450 isoforms, UGT1A1, PXR, and CAR. (B) The mRNA expression levels of CYP450 isoforms, UGT1A1, PXR, and CAR. KCZ (Ketoconazole): PXR inhibitors; RA (Retinoic acid): CAR inhibitors. The data were analyzed using a one-way analysis of variance (ANOVA), and the differences between the means of two groups were compared using LSD tests. * indicates the significance of experimental groups, compared with that of the control. Values were expressed as Mean ± SEM (n = 3). Levels are considered significant at * p < 0.05.