Table 3.
Paraproteins and neoplastic involvement of bone marrow and extramedullary tissues in 16 cats with multiple myeloma
| Cat No. | Bence‐Jones Proteinuria | M‐protein | Bone Lesion | Spleen | Liver | Lymph Node | Cutaneous Plasma Cell Tumor | Bone Marrow Plasma Cells, % | Plasma Cells with Atypia, % | Flame Cells |
|---|---|---|---|---|---|---|---|---|---|---|
| 1 | − | Biclonal | + | ND* | ND | ND | − | 37 | 4 | Few |
| 2 | ND | Monoclonal | − | + | ND | ND | − | 17 | 48 | Many |
| 3 | + | ND | + | ND | ND | ND | − | 13 | 83 | − |
| 4 | − | Monoclonal | − | + | ND | ND | − | 14 | 79 | − |
| 5 | + | Monoclonal | + | ND | ND | ND | Multiple | >80 | 49 | Many |
| 6 | + | Biclonal | − | + | + | ND | − | ND | 89 | − |
| 7† | ND | Monoclonal | + | +‡ | +‡ | +‡ | − | >75‡ | ND‡ | − |
| 8 | + | Monoclonal | − | ND | ND | + | Single‡ | 73 | 34 | − |
| 9† | ND | ND | ND | +‡ | +‡ | +‡ | − | >75‡ | ND‡ | − |
| 10 | ND | Monoclonal | − | ND | ND | ND | − | >80 | 18 | − |
| 11 | − | Monoclonal | + | ND | ND | ND | − | 0 | − | − |
| 12 | ND | Monoclonal | − | ND | ND | ND | − | 36 | 0 | Few |
| 13 | − | Monoclonal | − | ND | ND | ND | − | 21 | 45 | − |
| 14 | − | Monoclonal | + | ND | ND | ND | − | >99‡ | ND‡ | − |
| 15 | ND | Monoclonal | NA | + | ND | + | − | 35 | 11 | − |
| 16 | ND | Biclonal | + | ND | ND | ND | − | 78 | 68 | − |
*ND indicates not determined.
†Diagnosis of multiple myeloma made at necropsy.
‡Organ/site involvement determined histologically; all other sites determined cytologically.