Figure 5.

PVT Suppresses the Growth of Pancreatic Tumors in BxPC3 Subcutaneous Xenograft Model

(A) Oral administration of 10mg/kg PVT everyday suppressed the growth of subcuateous BxPC3 tumor xenografts. (B) Western blot analysis of pAkt(Ser473), Akt, Gli1, and cleaved PARP in BxPC3 tumor lysates. β-Actin was used as a loading control. The protein expression in the control and treatment groups was normalized with the respective β-actin of each group. Each blot or FFPE represents a tumor from an individual mouse (B, C and D). Individual FFPE tumor tissues were sectioned and analyzed for (C) IHC and (D) TUNEL assays. Scale bars, 200 µm . The statistical significance level was considered to be p ≤ 0.05.