Fig. 8.

AZM198 prevents MPO‐induced cell death in vitro. To analyze the influence of MPO and AZM198 on hepatocytes, Hep‐G2 cells were incubated for 24 hours with 1‐mM fatty acids. Then, they were left untreated or incubated with 1 U/L MPO, 1 mU/L glucose oxidase, and either DMSO (0 µM AZM198) or AZM198 at a concentration of 0.5 µM, 1 µM, or 2 µM for 24 hours. Cell viability was measured by 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide assay (n = 8). Data are representative of three experiments and are presented as mean ± SEM. *P ≤ 0.05. Abbreviation: FA, fatty acid.