Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Sep 17;8:586578. doi: 10.3389/fcell.2020.586578

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Kuang, Liu, Tang and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

The role of mitochondria in ferroptosis and apoptosis. The loss of mitochondrial membrane potential (ΔΨm) and the production of ROS are implicated in ferroptosis and apoptosis by different pathways. Erastin can bind VDAC2 and VDAC3 to induce BID-dependent ferroptosis through ALOX, whereas BAK1 and BAX are required for staurosporine-induced apoptosis through CYCS. ALOX, lipoxygenase; BAK1/BAK, BCL2 antagonist/killer 1; BAX, BCL2-associated X, apoptosis regulator; BID, BH3 interacting domain death agonist; CYCS, cytochrome C, somatic; ROS, reactive oxygen species; VDAC, voltage-dependent anion channel.