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. 2020 Sep 17;8:571536. doi: 10.3389/fcell.2020.571536

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Copyright © 2020 Xiao and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of gastric stem cells in H. pylori infection and gastric carcinogenesis. (A) H. pylori can colonize in gastric surface cells, neck regions and even the base of antral glands. Gland-colonized bacteria directly or indirectly expands the stem cell pools. (B) Microinjection of H. pylori with gastric organoid can mimic the model of H. pylori infection in vitro, while co-culture model of H. pylori and organoid-derived primary gastric epithelial cells are more easier to investigate the pathogenesis of this bacterium. (C) The candidate stem cell origin and possible mechanism behind gastric oncogenesis.