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. 2020 Sep 17;8:524018. doi: 10.3389/fbioe.2020.524018

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Copyright © 2020 Macedo, Martínez, Barrias and Sarmento.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Scheme of the configuration of the three-dimensional (3D) intestinal model (3D Caco-2 and 3D Coculture). The 3D model is composed of a collagen layer with human intestinal fibroblasts embedded, and on top, Caco-2 and HT29-MTX epithelial cells are added in order to mimic the intestinal enterocytes and goblet cells, respectively.