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. 2020 Sep 17;8:524018. doi: 10.3389/fbioe.2020.524018

FIGURE 2.

FIGURE 2

Characterization of the collagen matrix. (A) Rheological behavior of the 6 mg/ml collagen hydrogels when subjected to frequency sweep tests (0.1–10 Hz) with a strain of 1% show that the elastic modulus of the disks is around 500 Pa, which is considered within normal lamina propria values. Results are the average of triplicates, and bars represent the standard error deviation (SEM). (B) Visualization of the 6 mg/ml collagen hydrogel surface by atomic force microscopy (AFM). Collagen gels present a highly porous surface, with porous sizes ranging from 1 to 10 μm. (C,D) Visualization of the 6 mg/ml collagen hydrogel inner structure by CryoSEM. Like its surface, the inner structure of the disks is highly porous, with random distribution and a size ranging from 1 to 10 μm.