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. 2020 Oct 1;149:104553. doi: 10.1016/j.micpath.2020.104553

Fig. 1.

Fig. 1

(a) Schematic structure of the virion of PEDV. (b) Schematic diagram of the genome of PEDV. Structural proteins, including spike (S), envelope (E), membrane (M) and nucleocapsid (N) proteins, as well as accessory proteins ORF3 and non-structural proteins derived from ppl1ab, including nsp1-16, papain-like proteinase (PLpro, nsp3), 3C-like proteinase (3CLpro, nsp5), RNA-dependent RNA polymerase (RdRp, nsp12), 5′-to-3′ Helicase (HEL, nsp13), exoribonuclease (ExoN, nsp14), endoribonuclease (EndoU, nsp15), 2′-O-methyltransferases (2′-O-MTase, nsp16). Spike protein, including signal peptide (SP, 1–18 aa), sialic acid-binding region (SIA, 19–233 aa), core neutralizing epitope (COE, 499–638 aa), fusion peptide (FP, 891–908 aa), heptad repeat domain (HR1, 978–1117 aa and HR2, 1274–1313 aa), transmembrane domain (TM, 1328–1350 aa), and cytoplasmic domain (CP, 1351–1386 aa).