Table 1.
Comparison of the Baseline Clinical Characteristics Between Patients With and Without Sarcopenia.
| Parameter | Overall (n = 115) | Sarcopenics (n = 55) | Nonsarcopenics (n = 60) | P value |
|---|---|---|---|---|
| Age (yrs) | 46.3 ± 10.2 | 45.2 ± 10.9 | 47.2 ± 9.3 | 0.51 |
| Gender (M:F) | 104 (90.4):11(9.6) | 51 (92.7): 4 (7.3) | 53(88.3): 7 (11.7) | 0.53 |
| BMI(Kg/m2) | 24.5 ± 4.3 | 23.1 ± 3.1 | 25.8 ± 4.9 | 0.14 |
| Disease severity scores | ||||
| Child-Pugh score | 10.6 ± 1.7 | 11.0 ± 1.6 | 10.2 ± 1.8 | 0.67 |
| Child A | 1 (0.87) | 0 (0.0) | 1(1.7) | 0.08 |
| Child B | 26 (22.6) | 8 (14.5) | 18(30.0) | |
| Child C | 88 (76.5) | 47 (85.5) | 41(68.3) | |
| MELD score | 20.6 ± 6.3 | 21.9 ± 7.0 | 19.5 ± 5.4 | 0.63 |
| MELD-Na score | 23.0 ± 6.6 | 24.8 ± 6.8 | 21.4 ± 5.9 | 0.39 |
| Primary Etiology | ||||
| Alcohol | 61 (53) | 26 (47.3) | 35 (58.4) | 0.66 |
| NASH | 34 (29.6) | 21 (38.2) | 13 (21.6) | |
| Viral | 12 (10.4) | 6 (11) | 6 (10) | |
| Others | 8(6.9) | 2 (3.5) | 6 (10) | |
| Clinical presentation | ||||
| Decompensated CLD | 97 (75.7) | 44 (80) | 53 (88.3) | 0.31 |
| ACLF | 18 (24.3) | 11 (20) | 7 (11.7) | |
| Presence of Ascites | 111 (96.5) | 55 (100) | 56 (93.3) | 0.051 |
| History of LVP | 57 (49.7) | 30 (54.5) | 27 (45) | 0.37 |
| Number of LVP sessions | ||||
| ≤2 sessions | – | 21 (38.1) | 25 (41.7) | 0.19 |
| ≥3 sessions | – | 9 (16.4) | 2 (3.3) | |
| History of complications | ||||
| SBP | 68 (59.1) | 26 (47.3) | 18 (30.0) | 0.12 |
| HE | 67 (58.2) | 35 (63.6) | 32 (53.3) | 0.26 |
| HPS | 45 (39.1) | 22 (40.0) | 23 (38.3) | 0.85 |
| AKI | 64 (55.7) | 37 (67.3) | 27 (45.0) | 0.016* |
| Requirement of dialysis | 9 (7.8) | 8 (14.5) | 1 (1.6) | 0.01* |
| Charlson Comorbidity Index (CCI) | ||||
| CCI score | 3.5 ± 1.4 | 3.8 ± 1.4 | 3.2 ± 1.3 | 0.026* |
| CCI score <3 | – | 26 (47.3) | 39 (65) | |
| CCI score ≥ 3 | – | 29 (52.7) | 21 (35) | 0.047* |
Data expressed as number (percentage) and mean ± SD.
*Significant at P < 0.05.
ACLF, Acute on chronic liver failure; MELD, Model for end-stage disease; NASH, Nonalcoholic steatohepatitis; HBV, Hepatitis B virus; HCV, Hepatitis C virus; CLD, Chronic liver disease; LVP, Large volume paracentesis; SBP, Spontaneous bacterial peritonitis; HE, Hepatic encephalopathy; HPS, Hepatopulmonary syndrome; AKI, Acute kidney injury; CCI, Charlson Comorbidity Index.