A: Knockout (KO) mice (Lrat-Cre Pdgfra−/− mice) have no reduction in serum markers of liver injury after bile duct ligation (BDL)–induced liver injury. KO and wild-type (WT) mice have no differences in alanine transaminase (ALT), aspartate transaminase (AST), alkaline phosphatase (ALP) total bilirubin, or direct bilirubin values at 14 days. B: Comparable longitudinal trends in serum ALT, AST, ALP, total bilirubin, or direct bilirubin values between KO and WT at 0 days, 5 days, or 14 days after BDL. n = 2 at 0 days, 3 at 5 days, and 3 at 14 days per genotype.