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. 2020 Oct;190(10):2080–2094. doi: 10.1016/j.ajpath.2020.06.006

Figure 4.

Figure 4

Decreased fibrosis at 4 weeks of carbon tetrachloride treatment coincides with fewer stellate cells in hepatic parenchyma. A: Representative liver sections from knockout (KO) mice (Lrat-Cre Pdgfra−/− mice) show fewer desmin-positive cells by immunohistochemistry (IHC) after 4 weeks of carbon tetrachloride injury compared with wild-type (WT) controls. No change in α-smooth muscle actin (α-SMA) IHC is observed at this time point. B: No change in desmin or α-SMA IHC is evident in KO versus WT controls at the 8-week carbon tetrachloride time point. C: Hydroxyproline assay shows comparable content hydroxyproline (micrograms) content per gram of hepatic tissue at 4 and 8 weeks of carbon tetrachloride treatment in WT versus KO mice. n = 7 KO mice at 4 weeks (A); n = 8 WT mice at 4 weeks (A) and KO mice at 8 weeks (B); n = 6 WT controls at 8 weeks (B). Original magnification, ×50 (A and B).