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. 2020 Oct;190(10):2080–2094. doi: 10.1016/j.ajpath.2020.06.006

Figure 6.

Figure 6

Improved serum transaminase profile in knockout (KO) mice (Lrat-Cre Pdgfra−/− mice) in the absence of hepatocellular proliferative advantage after carbon tetrachloride–mediated liver injury. A: KO and wild-type (WT) mice have similar alanine transaminase (ALT) and aspartate transaminase (AST) values at the 4-week carbon tetrachloride time point, whereas ALT and AST values in KO mice (red lines) are markedly lower than in WT mice (blue lines) at the 8-week carbon tetrachloride time point. B: Proliferating cell nuclear antigen immunohistochemistry shows no increase in hepatocellular proliferation in KO animals at the 4-week or 8-week carbon tetrachloride time points compared with WT controls. ∗P < 0.05. n = 4 KO mice (A) and WT mice (A and B); n = 5 KO mice (B). Original magnification, ×100.