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. 2020 Sep 30;10:16185. doi: 10.1038/s41598-020-73233-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transgenic (Tg) APPswe/PSEN1dE9 mice demonstrate MR signal enhancement in cortical brain regions relative to wild type (WT) counterparts at all dose levels of ADx-001. Box plots show signal changes (expressed as percentage) between pre-contrast and delayed post-contrast T1-weighted spin-echo (T1w-SE) images for (a) 0.20 mmol Gd/kg, (b) 0.15 mmol Gd/kg, and (c) 0.10 mmol Gd/kg dose levels of ADx-001. Similar signal changes are shown between pre-contrast and delayed post-contrast fast spin-echo inversion recovery (FSE-IR) images at (d) 0.20 mmol Gd/kg, (e) 0.15 mmol Gd/kg, and (f) 0.10 mmol Gd/kg dose levels. Six mice were tested for both genotypes (Tg and WT) at all three dose levels (0.20, 0.15, and 0.10 mmol Gd/kg) for a total of 36 mice. Wilcoxon rank-sum test: p < 0.05 (*) and p < 0.005 (**).