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. 2020 Sep 29;218(1):e20200030. doi: 10.1084/jem.20200030

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© 2020 Mishra et al.

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Figure 8. — TGF-β and Eomes coordinate to promote the survival of CD8⁺ T reg cells. (A) Relative MFI of CD122 in different subsets of CD8⁺ T cells in naive WT spleen is shown (n = 11). (B) CD122 expression on pregated CD44^hiCD8⁺ T cells. (C) Relative MFI of Bcl-2 in different subsets of CD8⁺ T cells in naive WT spleen (n = 11). (D) Representative FACS profiles of pregated CD8⁺ T reg cells. (E) Relative MFI of Bcl-2 in pregated CD8⁺ T reg cells. Each line in A and C and each symbol in B and E represents the results from an individual mouse; bar graphs indicate the mean (± SEM). All mice are 3–6 mo of age. Pooled results from three (A and C) or six (B and E) independent experiments are shown. N.S., not significant; **, P < 0.01; ****, P < 0.0001 by paired (A and C) or unpaired (B and E) Student’s t test. WT, n = 27 (B) or 26 (D and E); Eomes^−/−, n = 17 (B) or 15 (D and E); Tgfbr2^−/−, n = 13 (B) or 12 (D and E); and Tgfbr2^−/−Eomes^−/−, n = 13 (B) or 12 (D and E).