. 2020 Sep 21;2020:1942849. doi: 10.1155/2020/1942849

Table 7.

Pharmacokinetic parameters of the 6 alkaloids in plasma (n = 6).

Alkaloids	Groups	AUC_0‐t (ng/h/mL)	t _1/2z (h)	T _max (h)	C _max (ng/mL)
AC	RCP	10.31 ± 3.56	2.29 ± 0.70	0.50 ± 0.00	7.23 ± 3.24
	HCP	4.96 ± 1.72^∗^##	2.95 ± 1.89^##	2.38 ± 0.69^∗∗	2.31 ± 1.16^∗∗^#
	RCD	1.75 ± 0.04^∗∗	0.88 ± 0.00^∗∗	3.00 ± 0.00^∗∗	0.83 ± 0.19^∗∗
	HCD	3.88 ± 0.23^∗^##	2.73 ± 1.19^##	2.50 ± 0.71^∗∗	1.60 ± 0.35^∗∗^#

MA	RCP	77.12 ± 1.73	0.90 ± 0.06	0.50 ± 0.00	37.03 ± 1.35
	HCP	46.90 ± 16.99^∗^##	2.78 ± 1.59^∗^##	2.17 ± 0.68^∗∗	19.83 ± 9.03^∗∗^#
	RCD	10.23 ± 3.22^∗∗	0.30 ± 0.03^∗∗	2.25 ± 0.47^∗∗	5.89 ± 2.22^∗∗
	HCD	61.86 ± 3.92^##	2.56 ± 1.94^∗^##	1.33 ± 0.44	25.88 ± 4.30^∗∗^##

HA	RCP	25.88 ± 1.90	1.61 ± 0.66	0.83 ± 0.26	16.07 ± 4.54
	HCP	22.43 ± 9.68	3.37 ± 1.49^∗^##	2.00 ± 0.89^∗^#	10.58 ± 6.86
	RCD	27.15 ± 4.43	0.88 ± 0.00^∗	0.5 ± 0.00	14.75 ± 5.80
	HCD	26.23 ± 6.73	4.45 ± 1.13^∗∗^##	1.33 ± 0.44	10.81 ± 1.46

BAC	RCP	6.74 ± 0.68	1.12 ± 0.18	0.5 ± 0.00	4.44 ± 0.72
	HCP	2.97 ± 0.60^∗∗	0.58 ± 0.17	0.83 ± 0.29	1.79 ± 0.25^∗∗
	RCD	—	—	—	—
	HCD	—	—	—	—

BMA	RCP	42.34 ± 8.49	0.97 ± 0.2	0.83 ± 0.52	27.86 ± 6.96
	HCP	17.28 ± 5.36^∗∗^#	4.68 ± 0.96^∗∗	2.00 ± 0.65^∗	7.67 ± 0.89^∗∗
	RCD	29.58 ± 4.91	6.65 ± 1.98^∗∗	1.5 ± 0.00	10.25 ± 0.94^∗
	HCD	15.29 ± 4.61^∗∗^#	1.8 ± 0.00^∗^##	2.67 ± 0.53^∗	6.38 ± 2.34^∗∗

BHA	RCP	16.76 ± 2.12	0.85 ± 0.30	1.50 ± 0.13	9.93 ± 1.83
	HCP	3.54 ± 0.55^∗∗	1.33 ± 0.58	1.00 ± 0.55	3.16 ± 0.79^∗∗
	RCD	—	—	—	—
	HCD	—	—	—	—

Mean ± S.D., n = 6. ^∗p < 0.05 and ^∗∗p < 0.01 vs. RCP group; ^#p < 0.05 and ^##p < 0.01 vs. RCD group.