Fig. 13.

Effect of CO treatment using H&E staining in liver of control, APAP and APAP + CO groups. Liver from control-group rats showed normal portal hepatic tissue and hepatic cells (A). The APAP group showed an aggregate of inflammatory cells in the portal triads and hydropic degeneration of some hepatocytes, which had pyknotic nuclei (B). The APAP + CO (50, 100 and 200 mg) group showed partial degeneration of hepatic cells and the prevention of inflammatory cell aggregation in hepatic triads (C, D and E). Magnification, 40 × .