Table 1.
Biochemical effects of cinnamon oil in serum of APAP induced hepatotoxicity in rats.
| Parameters | Control | Cinnamon oil (200 mg/kg b.w.) | APAP | APAP + Cinnamon oil (mg/kg b.w.) |
||
|---|---|---|---|---|---|---|
| 50 | 100 | 200 | ||||
| ALT (IU/L) | 4.2 ± 0.41 | 6.42 ± 0.52 | 10.71 ± 0.38*** | 9.07 ± 0.81 | 8.67 ± 0.40 | 3.74 ± 0.31### |
| AST (IU/L) | 18.16 ± 2.71 | 20.98 ± 1.89 | 45.36 ± 1.21*** | 36.67 ± 0.96## | 26.5 ± 1.75## | 17.61 ± 0.51### |
| ALP (IU/L) | 209.79 ± 6.9 | 206.34 ± 13.11 | 481.73 ± 21.45*** | 383.32 ± 17.10## | 310.59 ± 21.09### | 282.57 ± 12.76### |
| Bilirubin | 0.16 ± 0.12 | 0.13 ± 0.09 | 0.39 ± 0.07*** | 0.21 ± 0.16## | 0.17 ± 0.08### | 0.14 ± 0.06### |
| Albumin | 4.4 ± 0.67 | 4.2 ± 0.46 | 4.2 ± 0.43ns | 4.2 ± 1.5ns | 4.72 ± 0.82ns | 3.96 ± 0.63ns |
| Total protein (g/dL) | 7.36 ± 1.41 | 7.44 ± 0.89 | 7.36 ± 0.64ns | 9.023 ± 1.84ns | 7.91 ± 0.52ns | 7.96 ± 0.73ns |
Estimation of serum biomarkers in APAP induces hepatotoxicity in rats. CO treatment significantly reveres the serum markers in APAP + CO group as compared to the APAP group. Values are expressed as mean ± S.E.M of n = 6 animals. Significance was determined by one-way ANOVA followed by Tukey-Kramer post-hoc test for multiple comparisons. (ns = non-significant).
***p < 0.001 APAP vs. control.
##p < 0.01, ###p < 0.001 APAP + CO vs. APAP.