. 2020 Sep 17;7:1296–1304. doi: 10.1016/j.toxrep.2020.09.008

Table 2.

Biochemical effects of cinnamon oil in liver homogenate of APAP induced hepatotoxicity in rats.

Parameters	Control	Cinnamon oil (200 mg/kg b.w.)	APAP	APAP + Cinnamon oil (mg/kg b.w.)
Parameters	Control	Cinnamon oil (200 mg/kg b.w.)	APAP	50	100	200
ALT (IU/L)	34.28 ± 2.34	24.64 ± 1.67	358.95 ± 24.11***	133 ± 19.81^###	130.43 ± 13.37^###	64 ± 10.09^###
AST (IU/L)	12.5 ± 2.13	12.67 ± 1.65	16.5 ± 3.21**	15.25 ± 3.11	14 ± 0.98^#	13.5 ± 0.76^##
ALP (IU/L)	186.3 ± 24.45	178 ± 21.85	302.5 ± 22.37***	196 ± 19.65^##	163 ± 9.08^###	41.33 ± 7.59^###
Bilirubin	2.35 ± 0.76	2.28 ± 0.12	3.06 ± 1.2*	2.13 ± 0.09^#	0.66 ± 0.17^###	0.18 ± 0.06^###
Albumin	0.80 ± 0.03	0.73 ± 0.12	0.86 ± 1.04^ns	0.83 ± 0.11^ns	0.81 ± 0.87^ns	0.78 ± 0.09^ns
Total protein (g/dL)	1.017 ± 0.19	0.98 ± 1.09	1.57 ± 0.98^ns	1.54 ± 0.46^ns	1.42 ± 1.76^ns	1.36 ± 1.18^ns

Estimation of tissue homogenate biomarkers in APAP induces hepatotoxicity in rats. CO treatment significantly reveres the markers in APAP + CO group as compared to the APAP group. Values are expressed as mean ± S.E.M of n = 6 animals. Significance was determined by one-way ANOVA followed by Tukey-Kramer post-hoc test for multiple comparisons. (ns = non-significant).

*p < 0.05; **p < 0.01; ***p < 0.001 APAP vs. control.

^#p < 0.05; ^##p < 0.01, ^###p < 0.001 APAP + CO vs. APAP.