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. 2020 Sep 30;10:16117. doi: 10.1038/s41598-020-73008-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Activation of GPR35 by HMOs. (a) Dose response of GPR35 activation in arrestin mode by 6′SL, LNT and equimolar 6′SL + LNT. The concentrations indicated are total concentrations of HMOs. The responses of the three concentrations of 6 HMOs (from Fig. 1) are indicated. (b) Dose response of GPR35 stimulation in arrestin mode by 3′SL, LNnT, 2′FL and DiFL showing no activation of the receptor by any of those HMOs. (c) Responses of GPR35 in arrestin mode to equimolar LNT and 6′SL or to LNT and 6′SL at a ratio of 1.8, showing no difference between ratios of 1:1 and 1.8:1. The concentrations shown are total concentration of HMOs.