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. 2020 Sep 30;10:16131. doi: 10.1038/s41598-020-72903-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Increased inflammation and decreased ILCs in DJ-1^−/− mice. (a) Calprotectin level (mean ± SEM) measured by ELISA in DJ-1^+/+ and DJ-1^−/− mice fecal samples (n = 5). (b) DJ-1^−/− mice have significantly higher production of the MCP-1 (mean ± SEM) cytokine measurement from the feces. * represents the p value of < 0.05 using Student’s unpaired t-test. (c) Original Immunoblots from GFAP/Gapdh expression and quantification of the protein expression. Images used in the manuscript were cropped from the original blots which are shown in Suppl. Figure 7 and contrast was adjusted to make the image uniform. Bar diagram (mean ± SEM) shows the statistical significantly higher expression of GFAP in the colon tissues of the DJ-1^−/− mice compared to control DJ-1^+/+ mice (n = 7–9) from two different cohorts. (d) Left hand side figure shows representative FACS plots from DJ-1^+/+ and DJ-1^−/− mice spleen samples. X-axis represents Lineage markers of lymphoid cells (CD3, CD5, CD3, CD11b, CD11c, F4/80, Gr-1, B220 or CD19, and Ter119) and y-axis represents lymphoid marker CD45. Right hand side Bar diagram (mean ± SEM) shows significantly lower in DJ-1^−/− (n = 12) compared with DJ-1^+/+ (n = 11) from three different cohorts. *represents the p value of < 0.05 using Student’s unpaired t-test.

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