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PK profiles over 29 days after SOI of the five healthy volunteers dosed with 150, 450, 1350, 4050, and 12,150 mg, respectively, (A) and zoomed view on the first 48 h (B). Dose correlations with total area under the curve (AUC0–inf) (C), clearance (D), and half-life (Thalf), (E) showing dose linearity for the AUC0–inf, a stable clearance, and Thalf independent from dose.
