Table 2. HDIT101 surrogate peptide Candidates and Their Characteristics.
| HC/LC | amino acid sequence | peptide reference | length (amino acids) | cysteine | CDR sequence |
|---|---|---|---|---|---|
| HC | ALEWLAHIWWNNDK | HC1 | 14 | no | yes |
| HC | ESGPALVKPTQTLTLTCTFSGFSLSTSGMSVGWIR | HC2 | 35 | yes | yes |
| HC | IYYGYRPYAMDYWGQGTLVTVSSASTK | HC3 | 27 | no | yes |
| LC | SSQSIVHSBGBTYLEWYLQKPGQSPQLLIYKa | LC1 | 31 | no | yes |
| LC | VEAEDVGVYYCFQGSHVPWSFGQGTK | LC2 | 26 | yes | yes |
a
The underlined leucine residues indicate the positions for the stable isotope labeling of the LC1 peptide. CDR: complementarity-determining region; HC: heavy chain; LC: light chain.